Tanshinone IIA promotes ferroptosis in cutaneous melanoma via STAT1-mediated upregulation of PTGS2 expression
This study, the first to link Tan IIA-induced ferroptosis to the STAT1/PTGS2 axis in melanoma, identifies STAT1 and PTGS2 as novel therapeutic targets for melanoma, which demonstrates the potential of natural compounds Tan IIA in overcoming drug resistance and integrates traditional medicine with advanced molecular techniques for mechanistic exploration.
Authors
- Huiqing Xie
- Peiting Li
- Jian-Da Zhou (ORCID: https://orcid.org/0000-0002-5647-7583)
- Cong Peng (ORCID: https://orcid.org/0000-0001-7104-5490)
- Tianyu Li (ORCID: https://orcid.org/0000-0002-7940-0378)
- Can Liu (ORCID: https://orcid.org/0000-0001-5400-1242)
- Shijie Tang (ORCID: https://orcid.org/0009-0008-3917-643X)
- Shuyue Chen (ORCID: https://orcid.org/0000-0002-8132-6285)
- Ke Shi (ORCID: https://orcid.org/0000-0002-8213-3469)
- Wancong Zhang
Institutions
- Central South University (CN)
- Shantou University (CN)
- Nanyang Institute of Technology (CN)
- Second Affiliated Hospital of Shantou University Medical College (CN)
- Nanyang Medical College (CN)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1016/j.phymed.2025.156702
- Citations
- 10
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 9.36
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province