A novel approach to studying infective endocarditis: Ultrasound-guided wire injury and bacterial challenge in mice
Echocardiography and ex vivo histological staining demonstrated consistent infective endocarditis induction in our new model, combining a wire injury-induced endothelial damage and S. aureus administration. Further exploration of the initial immune cell response and biomarker expression could potentially identify indicators for early IE diagnosis and novel treatment targets.
Authors
- Ansgar Ackerschott (ORCID: https://orcid.org/0000-0001-6473-2399)
- Georg Nickenig
- Jessica Lambertz
- Benedikt Bartsch (ORCID: https://orcid.org/0000-0002-3126-221X)
- Mark Coburn (ORCID: https://orcid.org/0000-0002-7930-0270)
- Lars Fester (ORCID: https://orcid.org/0009-0005-3588-5333)
- Marijo Parčina (ORCID: https://orcid.org/0009-0005-2275-633X)
- Muntadher Al Zaidi (ORCID: https://orcid.org/0000-0002-3534-3121)
- Sebastian Zimmer (ORCID: https://orcid.org/0000-0002-1531-2088)
- Raúl Nicolás Jamin (ORCID: https://orcid.org/0009-0003-2084-8463)
- Christina Weisheit (ORCID: https://orcid.org/0000-0002-7647-1613)
- Moritz Altrogge (ORCID: https://orcid.org/0009-0002-6060-7966)
- Mariam Louis Fathy Nazir
Institutions
- University of Bonn (DE)
- University Hospital Bonn (DE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1371/journal.pone.0318955
- Citations
- 1
- Primary Topic
- Infective Endocarditis Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Deutsche Forschungsgemeinschaft