Age at menarche and risk of non-alcoholic fatty liver disease: Insights from the NHANES 2017–2020 and Mendelian randomization analyses
Our findings indicate a potential causal association between AAM and NAFLD, suggesting that early AAM may serve as a potential risk marker for NAFLD. This highlights the importance of incorporating AAM into clinical risk assessment tools and developing targeted prevention strategies for at-risk populations. Further research is needed to clarify the underlying mechanisms and to explore the potential benefits of early intervention.
Authors
- Xuemin Yuan (ORCID: https://orcid.org/0000-0002-3223-0762)
- Yueya Ge
- Xianli Lv (ORCID: https://orcid.org/0000-0001-8270-8464)
- Dongxiao Hao (ORCID: https://orcid.org/0000-0002-0659-7210)
- Changchun Wang (ORCID: https://orcid.org/0000-0003-3183-2160)
- Yuquan Li (ORCID: https://orcid.org/0009-0007-0024-0732)
- Xuemei Chen (ORCID: https://orcid.org/0000-0001-5614-6859)
- Xiuping Li (ORCID: https://orcid.org/0000-0003-4350-9651)
- Guifei Si
- Rui Zhang (ORCID: https://orcid.org/0009-0001-2573-7055)
Institutions
- Linyi University (CN)
- Linyi People's Hospital (CN)
- Second Hospital of Shandong University (CN)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1016/j.exger.2025.112748
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35