The Association between Intranasal Esketamine and Treatment-emergent Insomnia in the Treatment of Treatment-resistant Major Depression: A Meta-analysis
IN esketamine does not affect the occurrence of insomnia as an AE in the treatment of TRD. This contrasts previous findings demonstrating beneficial effects of esketamine on insomnia severity relative to placebo, although AE reporting may not capture insomnia improvements in a population with frequent baseline insomnia.
Authors
- Jeanine Kamphuis
- Robert A. Schoevers (ORCID: https://orcid.org/0000-0003-0760-9866)
- Anne-Fleur Zandbergen (ORCID: https://orcid.org/0009-0001-0091-342X)
- Jens H. van Dalfsen (ORCID: https://orcid.org/0000-0002-4388-8447)
- Cagdas Türkmen (ORCID: https://orcid.org/0000-0003-1147-612X)
- Wolfgang Viechtbauer (ORCID: https://orcid.org/0000-0003-3463-4063)
- Rutger Boesjes (ORCID: https://orcid.org/0009-0007-2495-8554)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Maastricht University (NL)
- Central Institute of Mental Health (DE)
Publication Details
- Journal
- Clinical Psychopharmacology and Neuroscience
- Published
- 2025-04-07
- DOI
- https://doi.org/10.9758/cpn.25.1271
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00