A novel indirubin- 3-monoxime derivative I3MV- 8b exhibits remarkable cytotoxicity against multiple myeloma by targeting TRIM28
I3MV- 8b offers a novel dual inhibition strategy targeting proteasome and autophagy, presenting a promising therapeutic option for MM.
Authors
- Shiyi Xie
- Lanting Liu
- Lugui Qiu (ORCID: https://orcid.org/0000-0002-8752-0644)
- Yan Li (ORCID: https://orcid.org/0000-0002-0068-5439)
- Gang An (ORCID: https://orcid.org/0000-0003-4922-4614)
- Teng Fang (ORCID: https://orcid.org/0000-0002-8629-3742)
- Zhentao Yu (ORCID: https://orcid.org/0000-0002-5785-8492)
- Mu Hao (ORCID: https://orcid.org/0000-0001-8621-4840)
- Bin He (ORCID: https://orcid.org/0000-0001-6884-6166)
- Hao Sun (ORCID: https://orcid.org/0000-0002-8270-6183)
- Xiaoyu Zhang (ORCID: https://orcid.org/0009-0000-0849-5579)
- Yonglong Zhao
- Xiyue Sun
- Lixin Gong (ORCID: https://orcid.org/0000-0001-7364-5588)
Institutions
- Guiyang Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing United Family Hospital (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s40364-025-00773-3
- Citations
- 2
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Guizhou Science and Technology Department
- Chinese Academy of Medical Sciences
- National Science and Technology Major Project