Differential involvement of neurotransmitter pathways in AD, bvFTD and MCI: Whole-brain MRI analysis
We identified distinct atrophy patterns linked to specific neurotransmitter systems, each showing unique neurochemical profiles. In AD, precuneus and inferior parietal lobules atrophy aligns with dopaminergic and GABAergic receptors, potentially impacting memory and executive functions. In bvFTD, medial orbitofrontal and temporal atrophy, is linked to mu-opioid receptor impairment, possibly contributing to behavioral symptoms. In MCI, early serotonergic dysregulation involving SERT occurs before detectable atrophy.
Authors
- Tiago Gil Oliveira (ORCID: https://orcid.org/0000-0003-0509-0562)
- Cemal Koba (ORCID: https://orcid.org/0000-0001-7097-1441)
- José Maria Sousa (ORCID: https://orcid.org/0000-0002-8839-1055)
- Isabel Santana (ORCID: https://orcid.org/0000-0002-8114-9434)
- Tiago Jesus (ORCID: https://orcid.org/0000-0003-1437-5439)
- L. de Andrés
- Inês Baldeiras (ORCID: https://orcid.org/0000-0002-8106-7308)
- Ricardo Félix Morais
Institutions
- Hospital de São João (PT)
- Universidad Nacional de Colombia (CO)
- Oxford Centre for Computational Neuroscience (GB)
- Institute for Systems Engineering and Computers (PT)
- Lukasiewicz Research Network - Krakow Institute of Technology (PL)
- Hospital Braga (PT)
- INESC TEC (PT)
- University of Coimbra (PT)
- University of Minho (PT)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1016/j.nbd.2025.106897
- Citations
- 9
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 12.88
Funders
- European Commission
- Fundacja na rzecz Nauki Polskiej
- Ministerstwo Edukacji i Nauki
- European Regional Development Fund