Acyclovir dosing strategies in herpes encephalitis: A retrospective charts review
Our study suggests that administering acyclovir based on actual body weight for non-obese patients and adjusted body weight for obese patients may enhance outcomes by promoting recovery and preventing toxicity. Multicenter prospective studies are needed to confirm such association and to provide clear guidelines of the most appropriate dosing of acyclovir in herpes encephalitis.
Authors
- Sherif Hanafy Mahmoud (ORCID: https://orcid.org/0000-0002-5517-2622)
- Maged Kharouba
- Asma Aboelezz
Institutions
- University of Alberta (CA)
Publication Details
- Journal
- Journal of Clinical Neuroscience
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.jocn.2025.111230
- Citations
- 8
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.83
Funders
- University of Alberta
- University Hospital Foundation
- Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta