Actin Binding to the BAR Domain and Arf GAP Activity of ASAP1 Coordinately Control Actin Stress Fibers and Focal Adhesions
Taken together, the results support the idea that ASAP1 coordinates the maintenance of FAs and SFs through integrated function of the BAR and GAP domains. We speculate that ASAP1 regulates SFs and their interaction with FAs through direct binding to components of the actin cytoskeleton. We discuss hypotheses related to this Arf-dependent activity of ASAP1 and propose the function of ASAP1 is not control of Arf•GTP levels.
Authors
- Hye Young Yoon (ORCID: https://orcid.org/0000-0001-9914-9507)
- Pei‐Wen Chen
- Sandeep Pallikkuth (ORCID: https://orcid.org/0009-0003-0400-6389)
- Paul A. Randazzo (ORCID: https://orcid.org/0000-0001-5349-0881)
- Jonah Unthank
Institutions
- Williams College (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- Biology of the Cell
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/boc.70005
- Citations
- 1
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.15