Effect of Chlorthalidone and Hydrochlorothiazide on 12-Hour vs 24-Hour Urinary Calcium Excretion
We conclude that the long-acting and more effective CTD is a preferable agent for stone prevention. Time of administration does not seem to be important, although morning administration may more effectively address higher postdinner calcium excretion. The most commonly used thiazide (HCTZ) is shorter acting, frequently dosed once per day, but does not seem to reduce UCa at this dose.
Authors
- John R. Asplin (ORCID: https://orcid.org/0000-0003-0977-1613)
- Daniel Arthur Wollin (ORCID: https://orcid.org/0000-0003-2913-0418)
- David S. Goldfarb (ORCID: https://orcid.org/0000-0002-9215-1273)
- Hassan Fattah
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Kentucky (US)
- VA NY Harbor Healthcare System (US)
- LabCorp (United States) (US)
- NYU Langone Health (US)
- New York University (US)
Publication Details
- Journal
- The Journal of Urology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1097/ju.0000000000004562
- Primary Topic
- Health and Well-being Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00