Three New Diterpenoids From <i>Phyllanthus emblica</i> Roots: Structure and Anti‐HIV Activity
Three undescribed aromatic diterpenoids (1-3), were isolated from the roots of Phyllanthus emblica and structurally characterized. Compounds 1 and 2 are cleistanthane-type diterpenoids, and the latter possesses a rare 4,5-seco-20(10→5)-abeo-ent-cleistanthane scaffold with an acetenyl at C-14. Compound 3 was elucidated as a new podocarpane trinorditerpenoid. The structural elucidation, including absolute configuration determination, was achieved through comprehensive spectroscopic analysis (nuclear magnetic resonance, mass spectrometry, ultraviolet, and infrared) combined with time-dependent density functional theory-based electronic circular dichroism calculations. Compound 2 showed potential activity against HIV-1<sub>Bal</sub> PsV infection with an IC<sub>50</sub> value of 3.30 µM.
Authors
- Zhou Bin (ORCID: https://orcid.org/0000-0002-2909-8764)
- Jian‐Min Yue (ORCID: https://orcid.org/0000-0002-4053-4870)
- Qian Wang (ORCID: https://orcid.org/0000-0002-9766-4617)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Nanchang University (CN)
- Chinese Academy of Sciences (CN)
- Fudan University (CN)
- Shanghai Institute of Materia Medica (CN)
- State Key Laboratory of Drug Research
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1002/cbdv.202500783
- Citations
- 1
- Primary Topic
- Phytochemistry and Bioactivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- National Natural Science Foundation of China
- Hainan University
- National Key Research and Development Program of China