Connected Speech Alterations and Progression in Patients With Primary Progressive Aphasia Variants
All models were equally effective in distinguishing the svPPA group from the other 2 PPA subtypes. However, compared with using standard measures alone, incorporating speech measures from the "Picnic Scene" speech test, GMVs, or their combination into the models significantly improved accuracy in differentiating nfvPPA and lvPPA groups. The PPA variants showed distinct speech trajectories. These variables can aid in understanding disease progression, predicting patient outcomes, and planning speech therapy interventions in clinical practice.
Authors
- Giuseppe Magnani (ORCID: https://orcid.org/0000-0001-8436-2903)
- Massimo Filippi (ORCID: https://orcid.org/0000-0002-5485-0479)
- Elisa Canu (ORCID: https://orcid.org/0000-0001-5804-3378)
- Elena Gatti (ORCID: https://orcid.org/0000-0002-5529-9850)
- Stefano Francesco Cappa (ORCID: https://orcid.org/0000-0003-1003-3925)
- Edoardo Gioele Spinelli (ORCID: https://orcid.org/0000-0003-1492-7221)
- Federica Agosta (ORCID: https://orcid.org/0000-0003-3121-4979)
- Veronica Castelnovo (ORCID: https://orcid.org/0000-0002-4125-9321)
- Cristina Villa (ORCID: https://orcid.org/0000-0002-2125-2886)
- Francesca Caso (ORCID: https://orcid.org/0000-0002-3072-1218)
- Paola Caroppo (ORCID: https://orcid.org/0000-0003-4274-9004)
- Stefano Pisano (ORCID: https://orcid.org/0009-0008-0523-9965)
- Sara Prioni (ORCID: https://orcid.org/0000-0001-9632-0591)
- Giordano Cecchetti (ORCID: https://orcid.org/0000-0002-6544-410X)
- Silvia Basaia (ORCID: https://orcid.org/0000-0002-0722-6243)
- Alessandra Lamanuzzi
- Laura Lumaca
- Sofia Santicioli
Institutions
- Vita-Salute San Raffaele University (IT)
- Istituto Universitario di Studi Superiori di Pavia (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000213524
- Citations
- 3
- Primary Topic
- Neurobiology of Language and Bilingualism
- Type
- article
- Field-Weighted Citation Impact
- 4.29