Efficacy and Safety of Autologous BCMA-directed mRNA CAR T-Cell Therapy in Generalized Myasthenia Gravis: Results from a Phase 2b Randomized Placebo-controlled Trial (S34.002)
Compare the effect of Descartes-08 versus placebo, as measured by the change in MG Composite (MGC) score from baseline to Month 3. Secondary: compare the effect of Descartes-08 versus placebo on MG-ADL and other measures of disease activity.
Authors
- Tuan Vu (ORCID: https://orcid.org/0000-0003-0724-0210)
- Michael H. Rivner (ORCID: https://orcid.org/0000-0002-6135-035X)
- James F. Howard (ORCID: https://orcid.org/0000-0002-7136-8617)
- George A. Small
- Hacer Durmuş Tekçe
- Metin Kurtoğlu
- Mamatha Pasnoor (ORCID: https://orcid.org/0000-0001-7424-4719)
- Marc Feinberg
- Gregory Sahagian
- Sheetal Shroff (ORCID: https://orcid.org/0000-0002-6317-4951)
- Hafsa Kamboh
- Zaeem A. Siddiqi (ORCID: https://orcid.org/0000-0003-2421-8381)
- Thomas Ragole
- Christopher M. Jewell (ORCID: https://orcid.org/0000-0002-6668-6928)
- Amanda Peltier (ORCID: https://orcid.org/0000-0003-1097-7715)
- Chafic Karam
- Miloš D. Miljković (ORCID: https://orcid.org/0000-0001-5848-6320)
- Carolina Barnett Tapia
- Mithila Vullaganti (ORCID: https://orcid.org/0000-0003-0673-7372)
- Tahseen Mozaffar (ORCID: https://orcid.org/0000-0002-1230-0188)
- Bennett Myers
Institutions
- Tufts Medical Center (US)
- University of Toronto (CA)
- Vanderbilt University (US)
- University of California, Irvine (US)
- University of South Florida (US)
- University of Alberta Hospital (CA)
- California University of Pennsylvania (US)
- Augusta University Health (US)
- Dent Neurologic Institute (US)
- Methodist Hospital (US)
- University of Kansas Medical Center (US)
- Neurology Center of Southern California (US)
- Istanbul University (TR)
- University of Colorado Denver (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000212220
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.09