Novel Bispecific Degrader BHV-1310 Eliminates Intravascular and Interstitial IgG within Multiple Organs and Anatomical Structures Including the Neuromuscular Junction (P4-8.002)
To investigate BHV-1310 clearance of human IgG through ASGPR mediated hepatic degradation in a murine mouse model.
Authors
- Bruce D. Car
- Hamid Yousuf
- David Pirman
- Gene M. Dubowchik (ORCID: https://orcid.org/0000-0001-9666-5733)
- Alani Estrella (ORCID: https://orcid.org/0000-0001-5447-6205)
- Anna Bunin
- Vlad Coric
- Wes Kazmierski
- David A. Spiegel (ORCID: https://orcid.org/0000-0002-1102-8012)
- Kathleen McGrath (ORCID: https://orcid.org/0000-0002-9345-1868)
- Seong Lee
- Silvina Del Carmen
Institutions
- Yale University (US)
- Biohaven Pharmaceuticals (United States) (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000211757
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00