Cortical Microglial Activation on [F-18]PBR06-PET Predicts Progression Independent of Relapse Activity (PIRA) in Multiple Sclerosis: A 4.5-year Longitudinal Study (S33.006)
The objectives of this study are to determine the ability of [F-18]PBR06-PET to predict progression independent of disease activity (PIRA) in multiple sclerosis (MS) and compare it with clinical measures, MRI volumetrics, and serum biomarkers .
Authors
- Bonnie I. Glanz (ORCID: https://orcid.org/0000-0002-4344-3456)
- Renxin Chu (ORCID: https://orcid.org/0000-0002-1668-238X)
- Rohit Bakshi
- Shrishti Saxena (ORCID: https://orcid.org/0000-0003-3429-5671)
- Kyle A. Sullivan (ORCID: https://orcid.org/0000-0002-4621-5598)
- Steven Cicero
- Tanuja Chitnis (ORCID: https://orcid.org/0000-0002-9897-4422)
- Howard L. Weiner (ORCID: https://orcid.org/0000-0003-0203-9681)
- Tarun Singhal (ORCID: https://orcid.org/0000-0001-6616-5113)
- Shipra Dubey (ORCID: https://orcid.org/0000-0003-1008-3041)
- Nicolas Horan
- Caleb Hansel
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000212261
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00