Aberrant Somatic Hypermutation Plays Minor Role in the Evolution of Molecular Alterations at Recurrence in PCNSL (P8-6.010)
This study investigates if aSHM is a driving event in recurrent/refractory CNS lymphoma by comparing genomic alterations in archival tumor from diagnosis with circulating tumor DNA (ctDNA) in the cerebrospinal fluid (CFS) at recurrence.
Authors
- Lisa Marie DeAngelis (ORCID: https://orcid.org/0000-0002-6290-7818)
- Lauren R. Schaff (ORCID: https://orcid.org/0000-0002-4664-670X)
- Christian Grommes
- Ingo K. Mellinghoff (ORCID: https://orcid.org/0000-0002-4347-8149)
- Jennifer Newman
Institutions
- Memorial Sloan Kettering Cancer Center (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000212197
- Primary Topic
- Photosynthetic Processes and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00