The Utilization of In Vitro Human-on-a-Chip Neural Networks to Assess Neurocognitive Impairment for Drug Safety and Efficacy (P5-3.015)
By combining microelectrode array (MEA) and human-induced pluripotent stem cell (hiPSC) technology, this study sought to validate the use of hiPSC-cortical neuron network long-term potentiation (LTP) for drug efficacy and safety studies for Alzheimer’s disease (AD) and anticholinergic cognitive burden (ACB), respectively.
Authors
- James J. Hickman (ORCID: https://orcid.org/0000-0002-1621-3006)
- Christopher J. Long (ORCID: https://orcid.org/0000-0002-2333-7576)
- Xiufang Guo (ORCID: https://orcid.org/0000-0002-3108-9349)
- Kaveena Autar
- David Morgan (ORCID: https://orcid.org/0000-0003-1224-7476)
- Jacques Turgeon (ORCID: https://orcid.org/0000-0002-7978-9280)
- Will Bogen
Institutions
- University of Central Florida (US)
- Grand Rapids Community College (US)
- Galena Biopharma (United States) (US)
- Michigan State University (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000211807
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00