Modeling the Human Corticospinal Tract-on-a-Chip (S5.004)

We developed an in vitro platform combining microfluidic devices and multielectrode array (MEA) to model the corticospinal tract (CST) using regionally specific human induced pluripotent stem cell-derived motor neurons (hiPSC-MN) and astrocytes (hiPSC-A). We hypothesize that this system promotes the maturation of both hiPSC-MN and hiPSC-A, providing a physiologically relevant model for studying Amyotrophic lateral sclerosis (ALS).