Unveiling Proteomic and Peptide-Level Modifications in Cerebrospinal Fluid and Plasma in Normal Cognitive Aging (P10-3.001)
This study aims to investigate age-associated changes in the proteome and peptide-level modifications in matched cerebrospinal fluid (CSF) and plasma samples from cognitively normal younger and older adults, focusing on post-translational modifications (PTMs) and alternative protein processing.
Authors
- Lukas Reiter (ORCID: https://orcid.org/0000-0001-5751-3139)
- Aida Kamalian (ORCID: https://orcid.org/0000-0002-6589-9083)
- Maria C.B. Luz
- Sara Ho (ORCID: https://orcid.org/0009-0004-5276-9249)
- Christopher Below (ORCID: https://orcid.org/0000-0003-1545-6281)
- Abhay Moghekar (ORCID: https://orcid.org/0000-0001-9464-1551)
- Roland Bruderer (ORCID: https://orcid.org/0000-0002-1049-5524)
- Polina Shichkova (ORCID: https://orcid.org/0000-0002-2574-1732)
- Marco Tognetti (ORCID: https://orcid.org/0000-0002-2379-1525)
- Yuehan Feng (ORCID: https://orcid.org/0000-0002-0094-3071)
Institutions
- Johns Hopkins University (US)
- Duke University (US)
- Biognosys (Switzerland) (CH)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000212456
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00