Rational Design of a Vaccine for Synucleinopathies Using Computationally-Derived Conformational B Cell Epitopes To Selectively Target Pathogenic Alpha-Synuclein Species (P8-3.007)
Design an optimal alpha-synuclein (ASyn) vaccine to elicit antibodies that selectively target toxic species of ASyn and avoid cross-reactivity with physiologic and non-toxic forms of ASyn.
Authors
- Ebrima Gibbs (ORCID: https://orcid.org/0000-0002-6383-9239)
- Joel C. Watts (ORCID: https://orcid.org/0000-0002-2604-2925)
- Erin Scruten (ORCID: https://orcid.org/0000-0001-5307-5717)
- Johanne Kaplan
- Juliane Coutts
- Marco A. M. Prado (ORCID: https://orcid.org/0000-0002-3028-5778)
- Neil R. Cashman (ORCID: https://orcid.org/0000-0002-0080-1006)
- Scott Napper (ORCID: https://orcid.org/0000-0003-1948-4538)
Institutions
- Western University (CA)
- University of British Columbia (CA)
- University of Toronto (CA)
- University of Saskatchewan (CA)
- Amorfix (Canada) (CA)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000210563
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.00