Investigating PINCH in Glioblastoma Multiforme: A Potential Adjuvant Therapy Target to Improve Treatment Outcomes (P4-6.012)

This study investigated the role of particularly-interesting-new-cysteine-histidine-rich protein-1 (PINCH1) in glioblastoma multiforme (GBM) progression and recurrence, as well as PINCH’s potential as a therapeutic target. The study focuses on understanding how changes in PINCH1 protein expression and post-translational modifications (PTM) impact cell cycle dynamics and cell survival upon chemotherapeutic agent exposure. Understanding PINCH1’s role in GBM development/progression may lead to improved treatment approaches.