Clinicopathological Correlations in Anti-GAD65 and Anti-Glycine Neurologic Autoimmunity: Linking Excitatory Phenotypes to Inhibitory Neuron Dysfunction (P2-8.016)
This study investigates four pathological evaluations of stiff person syndrome spectrum disorder (SPSD) and GAD65-associated epilepsy. While serostatus varied, all patients exhibited similar excitatory clinical phenotypes and histological evidence of disrupted inhibitory neuron function, suggesting a shared pathogenic mechanism beyond antibody status.
Authors
- Aaron Carlson (ORCID: https://orcid.org/0000-0001-7520-7864)
- Ann-Charlotte Granholm-Bentley
- Ken Jones (ORCID: https://orcid.org/0000-0002-4646-1000)
- Amanda L. Piquet (ORCID: https://orcid.org/0000-0001-7349-6455)
- Samuel Aragon
- Samuel J. Guzman (ORCID: https://orcid.org/0000-0001-7029-978X)
- Jeremiah Phares
- Mary Benson
- Candace Bretsch
- Campbell Pontin
- Angus Tolan
Institutions
- University of Colorado System (US)
- Children's Hospital Colorado (US)
- Neurology, Inc (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000211902
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00