Cardiac Arrest: A Rare Complication of Intra Thecal Baclofen Withdrawal (P10-7.008)

Baclofen, a gamma-aminobutyric acid(GABA)receptor agonist, is used for the management of spasticity in neuromuscular disorders. Intrathecal(IT) route is indicated in cases of severe spasticity associated with spinal cord injury with side effects profile. Baclofen withdrawal symptoms can happen after IT pump removal which can present as pruritus, anxiety, or severe symptoms like paranoia, psychosis, seizures, hallucinations, severe spasticity and dyskinesia. Cardiac arrest after baclofen withdrawal is rare with only 2 cases in literature so far however in both cases IT-pump was replaced. We present a case of PEA arrest after baclofen IT-pump removal which was managed without replacing.

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Publication Details

Journal
Neurology
Published
2025-04-07
DOI
https://doi.org/10.1212/wnl.0000000000210718
Primary Topic
Botulinum Toxin and Related Neurological Disorders
Type
article
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article

Cardiac Arrest: A Rare Complication of Intra Thecal Baclofen Withdrawal (P10-7.008)

Kshitiz Singh, Niraj Arora
Neurology
Botulinum Toxin and Related Neurological Disorders
article

Cardiac Arrest: A Rare Complication of Intra Thecal Baclofen Withdrawal (P10-7.008)

Kshitiz Singh, Niraj Arora
article en

Abstract

Baclofen, a gamma-aminobutyric acid(GABA)receptor agonist, is used for the management of spasticity in neuromuscular disorders. Intrathecal(IT) route is indicated in cases of severe spasticity associated with spinal cord injury with side effects profile. Baclofen withdrawal symptoms can happen after IT pump removal which can present as pruritus, anxiety, or severe symptoms like paranoia, psychosis, seizures, hallucinations, severe spasticity and dyskinesia. Cardiac arrest after baclofen withdrawal is rare with only 2 cases in literature so far however in both cases IT-pump was replaced. We present a case of PEA arrest after baclofen IT-pump removal which was managed without replacing.

NeurologyVol. 104(7_Supplement_1)
University of Missouri (US)
Good health and well-being
Openalex Percentile: Top 89%
Botulinum Toxin and Related Neurological Disorders
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