T1 and T2 Mapping Improves Correlation of Disability and Brain Atrophy Beyond Lesional Measures in Patients with Multiple Sclerosis (P3-1.015)
To assess the incremental predictive value for disability, measured by Expanded Disability Status Scale (EDSS) and normalized brain volume (nBV), of evaluating pathology in normal-appearing white matter (NAWM) using mapping of T1 and T2 Z-scores (T1M, T2M) along with T2 lesion volume (T2LV) in patients with multiple sclerosis (pwMS).
Authors
- Veronica Ravano (ORCID: https://orcid.org/0000-0002-1532-9664)
- Tom Hilbert (ORCID: https://orcid.org/0000-0001-8207-4908)
- Manuela Vaněčková (ORCID: https://orcid.org/0000-0002-8784-7997)
- Dana Horáková (ORCID: https://orcid.org/0000-0003-1915-0036)
- Tomáš Uher (ORCID: https://orcid.org/0000-0003-3160-9022)
- Jaroslav Lindner (ORCID: https://orcid.org/0000-0001-8432-4069)
- Michaela Andělová (ORCID: https://orcid.org/0000-0002-3812-7483)
- Bénédicte Maréchal (ORCID: https://orcid.org/0000-0001-7866-2854)
- Gian Franco Piredda (ORCID: https://orcid.org/0000-0002-8449-6634)
- Dominika Šťastná (ORCID: https://orcid.org/0000-0003-2418-4847)
- Tobias Kober (ORCID: https://orcid.org/0000-0001-7598-9456)
- Václav Čapek (ORCID: https://orcid.org/0000-0002-8574-7001)
- Matej Kudrna (ORCID: https://orcid.org/0009-0000-6694-5929)
- Johannes Disselhorst
Institutions
- Charles University (CZ)
- Siemens (Switzerland) (CH)
- General University Hospital in Prague (CZ)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000211268
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00