Novel Bispecific Degrader BHV-1310 Achieves Rapid, Robust, and Selective IgG Reduction in Preclinical Models including Nonhuman Primates (S18.009)
To investigate the pharmacodynamic effect of BHV-1310 on circulating immunoglobulin isotypes in rabbits and cynomolgus macaques
Authors
- Bruce D. Car
- Simone M. Nicholson (ORCID: https://orcid.org/0000-0003-0188-3936)
- David Pirman
- Elizabeth A. Dierks (ORCID: https://orcid.org/0000-0002-3654-4064)
- Gene M. Dubowchik (ORCID: https://orcid.org/0000-0001-9666-5733)
- Anna Bunin
- Vlad Coric
- Wes Kazmierski
- Neal Sharpe
- David A. Spiegel (ORCID: https://orcid.org/0000-0002-1102-8012)
- C Poole
Institutions
- Yale University (US)
- Biohaven Pharmaceuticals (United States) (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000212548
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00