Quantitation of Hypocretin Neuropeptides (Orexin-A and -B) in Human Cerebrospinal Fluid via HPLC with MS/MS Detection (P1-4.002)
We have developed a highly sensitive and specific LC-MS assay for the simultaneous measurement of intact biologically active Orexin-A and -B and fully validated it for use in CSF from human subjects.
Authors
- Kushal Shah
- Joe Palandra
- M. Shane Woolf (ORCID: https://orcid.org/0000-0001-8722-5410)
- Omnia A. Ismaiel (ORCID: https://orcid.org/0000-0003-3680-621X)
- William R. Mylott Jr (ORCID: https://orcid.org/0000-0001-7512-2131)
- Aaron Wheeler
- Meng Ye (ORCID: https://orcid.org/0000-0002-6785-0099)
- Jian‐Lin Wu (ORCID: https://orcid.org/0000-0002-3875-185X)
- Hui Yu (ORCID: https://orcid.org/0000-0002-6644-550X)
- Moucun Yuan (ORCID: https://orcid.org/0000-0001-7532-1296)
- Mike Baratta
- Alan K. Pierce
- Walter Wiley
Institutions
- Takeda (Japan) (JP)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000211942
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00