Rare Presentation of Anti-Yo Antibody Paraneoplastic Syndrome: Encephalitis and Axonal Sensorimotor Polyneuropathy in Covert Endometrial Carcinoma (P3-8.020)

We present an 81-year-old woman of atypical paraneoplastic syndrome that initially manifested as autoimmune encephalitis with seizures and speech disturbances. Her encephalitis was later complicated with progressive axonal sensorimotor polyneuropathy and anemia of chronic inflammation. Paraneoplastic panel showed strong anti-Yo antibody positive. Repeated cancer investigations revealed stage IIIc endometrial cancer.