Macrophage Galactose C-type Lectin Exacerbates MS Pathogenesis in EAE Murine Model (P6-1.001)

Multiple sclerosis (MS) is a chronic autoimmune disorder affecting the central nervous system (CNS), leading to neuroinflammation, gliosis, and neuronal loss. The human macrophage galactose-type lectin (MGL or CD301), a member of the C-type lectin receptor (CLR) family, is expressed by myeloid cells such as dendritic cells (DCs) and macrophages. In mice, the macrophage galactose-type lectin 2 (MGL2 or CD301b) receptor is homologous to the human MGL. This study investigates the role of MGL2 in the progression of experimental autoimmune encephalomyelitis (EAE), a murine model replicating MS disease.