Fibrin induces infiltration of macrophages and neutrophils via integrin <i>α</i>M<i>β</i>2 and triggers aortic dissection
Fibrin plays a crucial role in triggering AD through recruiting macrophages and neutrophils via integrin αMβ2. Regulation of fibrin deposition or inhibition of the interaction between fibrin and integrin αMβ2 provide a potential therapy against AD.
Authors
- Weiguo Fu (ORCID: https://orcid.org/0000-0002-0270-9377)
- Huiyuan Gao (ORCID: https://orcid.org/0000-0003-4672-8219)
- Zhihui Dong (ORCID: https://orcid.org/0000-0002-3754-2458)
- Lingwei Zou
- Mingbo Cao (ORCID: https://orcid.org/0000-0002-6445-2685)
- Jixiu Zhang
- Jie Li (ORCID: https://orcid.org/0009-0009-8536-7971)
- Yu Li (ORCID: https://orcid.org/0000-0002-1893-9046)
- Min Zhou (ORCID: https://orcid.org/0000-0002-7463-2938)
- Zhonghui Zhu
- Baohong Jiang (ORCID: https://orcid.org/0000-0002-8573-1536)
Institutions
- Shenyang Pharmaceutical University (CN)
- Nanjing University of Chinese Medicine (CN)
- Chinese Academy of Sciences (CN)
- Fudan University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Shanghai Institute of Materia Medica (CN)
- Zhongshan Hospital (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1111/bph.70033
- Citations
- 1
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Shanghai Science and Technology Development Foundation
- National Natural Science Foundation of China
- National Key Research and Development Program of China