Inhibition of DNA polymerase eta‐mediated translesion DNA synthesis with small molecule sensitises ovarian cancer stem‐like cells to chemotherapy
These results establish chrysin as a novel class of TLS inhibitors and highlight its potential as a chemotherapy adjuvant for overcoming chemoresistance and improving treatment outcomes in ovarian cancer.
Authors
- Rakesh Pathak (ORCID: https://orcid.org/0000-0001-7729-6223)
- Subhankar Bose (ORCID: https://orcid.org/0000-0003-1296-4985)
- Deepak Kumar (ORCID: https://orcid.org/0000-0002-8292-1684)
- Amit Kumar Dixit (ORCID: https://orcid.org/0000-0001-9544-4058)
- Mrinmoy Sarkar (ORCID: https://orcid.org/0000-0002-6798-8979)
- Md Tanjim Alam (ORCID: https://orcid.org/0000-0001-9678-9090)
- Amit Kumar Srivastava (ORCID: https://orcid.org/0000-0001-8219-4854)
- Bilash Chatterjee (ORCID: https://orcid.org/0000-0002-5388-540X)
- Priyanka Saha (ORCID: https://orcid.org/0000-0001-5106-9751)
- Prem Prakash Tripathi (ORCID: https://orcid.org/0000-0002-2583-8382)
Institutions
- Indian Institute of Chemical Biology (IN)
- Central Council for Research in Ayurvedic Science (IN)
- Indian Institute of Science Education and Research Berhampur (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1111/bph.70037
- Citations
- 2
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Council of Scientific and Industrial Research, India