Boosting of Innate Immunity and Induction of Trained Immunity through IgY in Chicks

To allow poultry to be produced with good producibility and safety with high-quality products, the avian immune system is essential. Vaccinations, feed supplements, and other treatments have been shown to improve innate immunity in a variety of animals throughout the last ten years. Based on this study, it is demonstrated whether synthetic IgY might effectively induce trained innate immunity in chickens to improve their defense mechanisms against viral infection. This study made use of 120 one-day-old chicks and assigned them to six categories; G1, chicks were given only natural ration and water; G2, chicks were treated with ND vaccine; Groups 3,4, and 5 were treated with IgY orally, IM, and SQ respectively; G6, chicks were treated orally by IgY+ND vaccine, all treatment done at 12th days old, after 3 weeks the blood has been collected and Hemagglutination inhibitions (HI) test performed for all chicks’ groups. The body weight significantly (P≤0.5) increased in week one and week two in groups that received IgY orally and synergistic group vs. the other group, while in week three, all groups that received IgY, more specifically oral route showed highly significant (P≤0.5) increasing vs. to the other groups. The IgY increased immunity in chicks after each challenge significantly vs. the other groups including the ND vaccine group, followed by the synergistic group also showed a peak in immunity (P≤0.5). According to the study, broiler chicks given chicken IgY had higher HI titters and higher protection rates, and the oral IgY produced better outcomes.