Intracranial Hemorrhage in the Setting of Elevated α-Tocopherol Levels (P10-7.010)

Vitamin E, or tocopherol, is a lipid-soluble antioxidant that inhibits lipid peroxidation and scavenges reactive oxygen species. Additionally, it may inhibit platelet aggregation and cellular proliferation and decrease the availability of clotting factors, such as vitamin K. Vitamin E supplementation is beneficial in preventing cardiovascular events. However, toxicity due to its anticoagulatory effects may cause hemorrhage. We present a case of intracerebral hemorrhage in a patient with elevated vitamin E levels and no known risk factors.

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Publication Details

Journal
Neurology
Published
2025-04-07
DOI
https://doi.org/10.1212/wnl.0000000000211322
Primary Topic
Cancer, Lipids, and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

Intracranial Hemorrhage in the Setting of Elevated α-Tocopherol Levels (P10-7.010)

Preet Varade, Bilal Darwish, Sarah Glisan
Neurology
Cancer, Lipids, and Metabolism
article

Intracranial Hemorrhage in the Setting of Elevated α-Tocopherol Levels (P10-7.010)

Preet Varade, Bilal Darwish, Sarah Glisan
article en

Abstract

Vitamin E, or tocopherol, is a lipid-soluble antioxidant that inhibits lipid peroxidation and scavenges reactive oxygen species. Additionally, it may inhibit platelet aggregation and cellular proliferation and decrease the availability of clotting factors, such as vitamin K. Vitamin E supplementation is beneficial in preventing cardiovascular events. However, toxicity due to its anticoagulatory effects may cause hemorrhage. We present a case of intracerebral hemorrhage in a patient with elevated vitamin E levels and no known risk factors.

NeurologyVol. 104(7_Supplement_1)
Lehigh Valley Health Network (US), Lehigh Valley Hospital (US)
Openalex Percentile: Top 92%
Cancer, Lipids, and Metabolism
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