Sensitivity of Digital Clinical Biomarker Endpoints to Detect Disease Progression during the 8-week Pretreatment Run-In Period in Proof-of-Concept ALS Study VGCS-50635-002 (S27.003)

To investigate the changes in molecular and clinical disease biomarkers during the 8-week pretreatment run-in period of the VRG50635 amyotrophic lateral sclerosis (ALS) proof-of-concept study.

Authors

Shichao Yue (ORCID: https://orcid.org/0000-0001-8892-343X)
Paula M. Sandler
Shane Raines (ORCID: https://orcid.org/0009-0007-0637-8476)
Philip Van Damme (ORCID: https://orcid.org/0000-0002-4010-2357)
Colleen O’Connell (ORCID: https://orcid.org/0000-0002-4760-4093)
Eino Solje (ORCID: https://orcid.org/0000-0001-9940-9524)
Angela Genge (ORCID: https://orcid.org/0000-0001-5587-9946)
J Haas
Rachel Levy
Ruben van Eijk
Hariharan Rahul (ORCID: https://orcid.org/0000-0002-9565-7667)
Ilse Hoffman (ORCID: https://orcid.org/0000-0002-2541-4117)
Dina Katabi (ORCID: https://orcid.org/0000-0003-4854-4157)
Anil Tarachandani
Manu Jokela (ORCID: https://orcid.org/0000-0002-7568-4684)
Brian C. Shook
Vikram Ramanarayanan (ORCID: https://orcid.org/0000-0001-7810-2769)
Irene Choi
Pentti J. Tienari (ORCID: https://orcid.org/0000-0001-5686-2900)
Hardik Kothare (ORCID: https://orcid.org/0000-0003-4305-0334)
William Tracewell
Ashwin Swami
Robert H. Scannevin (ORCID: https://orcid.org/0000-0002-5749-2785)
Diego Cadavid (ORCID: https://orcid.org/0000-0002-5361-3834)
Payal Nanavati
Martin U. Schmidt
Michael Neumann (ORCID: https://orcid.org/0000-0002-1023-9061)
Pranav Krishna
Meredith Bartlett
Leonard van den Berg (ORCID: https://orcid.org/0000-0003-2251-6000)
Rumen Hristove

Institutions

University of Eastern Finland (FI)
Utrecht University (NL)
Universitair Ziekenhuis Leuven (BE)
Helsinki University Hospital (FI)
Turku University Hospital (FI)
University Medical Center Utrecht (NL)
Finland University (FI)
Stan Cassidy Foundation (CA)
Genomics (United Kingdom) (GB)
McGill University (CA)

Publication Details

Journal: Neurology
Published: 2025-04-07
DOI: https://doi.org/10.1212/wnl.0000000000208661
Primary Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Type: article
Field-Weighted Citation Impact: 0.00

Sensitivity of Digital Clinical Biomarker Endpoints to Detect Disease Progression during the 8-week Pretreatment Run-In Period in Proof-of-Concept ALS Study VGCS-50635-002 (S27.003)

Shichao Yue, Paula M. Sandler, Shane Raines, Philip Van Damme, Colleen O’Connell, Eino Solje, Angela Genge, J Haas, Rachel Levy, Ruben van Eijk, Hariharan Rahul, Ilse Hoffman, Dina Katabi, Anil Tarachandani, Manu Jokela, Brian C. Shook, Vikram Ramanarayanan, Irene Choi, Pentti J. Tienari, Hardik Kothare, William Tracewell, Ashwin Swami, Robert H. Scannevin, Diego Cadavid, Payal Nanavati, Martin U. Schmidt, Michael Neumann, Pranav Krishna, Meredith Bartlett, Leonard van den Berg, Rumen Hristove

April 7, 2025article en

Sensitivity of Digital Clinical Biomarker Endpoints to Detect Disease Progression during the 8-week Pretreatment Run-In Period in Proof-of-Concept ALS Study VGCS-50635-002 (S27.003)

Authors

Institutions

Publication Details

Sensitivity of Digital Clinical Biomarker Endpoints to Detect Disease Progression during the 8-week Pretreatment Run-In Period in Proof-of-Concept ALS Study VGCS-50635-002 (S27.003)

Sensitivity of Digital Clinical Biomarker Endpoints to Detect Disease Progression during the 8-week Pretreatment Run-In Period in Proof-of-Concept ALS Study VGCS-50635-002 (S27.003)

Abstract

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