ATH-1105, a Small-molecule Positive Modulator of the Neurotrophic HGF System, is Neuroprotective in Co-culture of Human iPSC-derived Motor Neurons and Muscle (P9-11.025)
Demonstrate target engagement and the relevance of modulating the hepatocyte growth factor (HGF) system in human tissue to address ALS-related pathology.
Authors
- Kevin J. Church
- Sherif M. Reda
- Jewel Johnston (ORCID: https://orcid.org/0000-0003-2937-2919)
- Robert William Taylor (ORCID: https://orcid.org/0000-0002-7768-8873)
- Wei Wu (ORCID: https://orcid.org/0000-0002-0975-4613)
Institutions
- Athira Pharma (United States) (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000208769
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00