Exposure to Long- and Short-Chain Per- and Polyfluoroalkyl Substances in Mice and Ovarian-Related Outcomes: An <i>in Vivo</i> and <i>in Vitro</i> Study
Our study demonstrates that long-chain PFAS, particularly PFNA, act as a <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mtext>PPAR</mml:mtext><mml:mi>γ</mml:mi></mml:mrow></mml:math> agonist in granulosa cells to interfere with gonadotropin-dependent follicle growth, hormone secretion, and ovulation; and exposure to high levels of PFAS may cause adverse ovarian outcomes. https://doi.org/10.1289/EHP14876.
Authors
- Nataki C. Douglas (ORCID: https://orcid.org/0000-0001-8443-8875)
- Shuo Xiao (ORCID: https://orcid.org/0000-0001-7225-9132)
- Brian Buckley (ORCID: https://orcid.org/0000-0001-7336-4321)
- Ji-Yong Julie Kim
- Yihan Fan (ORCID: https://orcid.org/0000-0001-9290-5496)
- Margrit Urbanek (ORCID: https://orcid.org/0000-0001-6994-7110)
- Joanna E. Burdette (ORCID: https://orcid.org/0000-0002-7271-6847)
- Jiyang Zhang (ORCID: https://orcid.org/0000-0003-2099-9512)
- Hilly Yang
- Pawat Pattarawat (ORCID: https://orcid.org/0000-0002-0173-7763)
- Sarahna A Moyd (ORCID: https://orcid.org/0000-0001-7789-520X)
- Qiang Zhang (ORCID: https://orcid.org/0000-0002-8678-7013)
- Ying Zhang (ORCID: https://orcid.org/0000-0001-8070-6449)
- Tingjie Zhan (ORCID: https://orcid.org/0009-0004-6103-5626)
Institutions
- Emory University (US)
- University of California, Los Angeles (US)
- University of California System (US)
- University of Illinois Chicago (US)
- Rutgers Sexual and Reproductive Health and Rights (NL)
- Rutgers Health (US)
Publication Details
- Journal
- Environmental Health Perspectives
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1289/ehp14876
- Citations
- 16
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 13.76