Rat 3D Printed Induction Device (RAPID-3D): A 3D-Printed Device for Uniform and Reproducible Scald Burn Induction in Rats with Histological and Microvascular Validation
RAPID-3D generated highly consistent burn sizes (198 ± 3.54 mm<sup>2</sup>) across all rats, with low inter-animal variability. Histological analysis confirmed full-thickness epidermal necrosis and deep partial-thickness dermal damage (600-900 µm depth). Microvascular Trends: Perfusion dropped immediately post-burn, remained low at day 4, and gradually increased from day 9 onward, suggesting progressive neovascularization and vascular remodeling. RAPID-3D provides a standardized, reproducible, and clinically relevant scald burn model, eliminates operator-induced variability, enhances experimental consistency, and offers strong translational relevance for burn treatment development and wound healing research.
Authors
- Bogdan Hoinoiu (ORCID: https://orcid.org/0000-0002-5217-7655)
- Alexandru Nistor (ORCID: https://orcid.org/0000-0001-6215-5858)
- Rodica Heredea (ORCID: https://orcid.org/0000-0001-7634-4297)
- Oana-Janina Roșca
- Codruţa Şoica
- Călin Brandabur
Institutions
- Vrije Universiteit Brussel (BE)
- Victor Babeș University of Medicine and Pharmacy Timișoara (RO)
- DM3D Technology (United States) (US)
Publication Details
- Journal
- Biology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.3390/biology14040378
- Citations
- 2
- Primary Topic
- Burn Injury Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.71