Febrile temperature-regulated TRPV1 in CD4+ T cells mediates neuroinflammation in complex febrile seizures
These results highlight the critical interplay between adaptive and innate immunity in CFS. The TRPV1/NFATs/STAT3 signaling pathway regulates Th17 cell differentiation and function under febrile conditions, revealing a promising therapeutic target for intervention.
Authors
- Shuo Kong
- Jun Yin
- Wanhong Liu (ORCID: https://orcid.org/0000-0003-3385-219X)
- Song Han (ORCID: https://orcid.org/0000-0003-4659-4388)
- Jingyi Liang (ORCID: https://orcid.org/0000-0002-0450-552X)
- Na‐Qiong Wu (ORCID: https://orcid.org/0000-0002-1719-3369)
- Tao-Xiang Chen (ORCID: https://orcid.org/0000-0001-9723-3115)
- Yu Chen (ORCID: https://orcid.org/0000-0002-4513-3750)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-2050-6343)
- Jianming Xu (ORCID: https://orcid.org/0000-0003-4467-6021)
- Song Su (ORCID: https://orcid.org/0009-0006-3322-3624)
- Xianglei Jia
- Xin Liang (ORCID: https://orcid.org/0009-0009-5125-4821)
- Xiaohua He
- Biwen Peng
- Yuanteng Fan
Institutions
- Weifang Medical University (CN)
- Wuhan Donghu University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s12974-025-03421-7
- Citations
- 5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.21