Highly‐Selective Electrochemical Decarboxylative Late‐Stage Functionalization of Amino Acids
A unified electrochemical decarboxylative strategy for the site-selective construction of carbon-heteroatom bonds is disclosed herein. The metal- and catalyst-free decarboxylation provides access to the functionalization of C- and N-terminus from the simple amino acid feedstock. A wide variety of primary, secondary, and tertiary acids or alcohols were well tolerated. Late-stage functionalization using α-D-galactopyranose, di-peptide, steroid derivatives, and bio-active drug molecules established the robustness and synthesis potential of our approach.
Authors
- Debasis Banerjee (ORCID: https://orcid.org/0000-0001-8626-8742)
- Tristan von Münchow (ORCID: https://orcid.org/0000-0002-8911-6733)
- Lutz Ackermann (ORCID: https://orcid.org/0000-0001-7034-8772)
- Adrija Ghosh (ORCID: https://orcid.org/0000-0002-4426-6113)
- Vishal Kumar Parida
Institutions
- Indian Institute of Technology Roorkee (IN)
- University of Göttingen (DE)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1002/chem.202501287
- Citations
- 3
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Alexander von Humboldt-Stiftung
- Department of Science and Technology, Ministry of Science and Technology, India
- Deutsche Forschungsgemeinschaft
- Indian Institute of Technology Roorkee
- Ministry of Education, India
- Leibniz-Gemeinschaft
- Science and Engineering Research Board