COVID‐19 Challenges in Autoimmune Hepatitis Management: A Successful Outcome With Intravenous Immune Globulin (IVIg)

<b>Background:</b> Several autoimmune diseases, such as autoimmune hepatitis (AIH), can arise or become decompensated following COVID-19 infection or vaccination; however, there is a lack of data regarding the management of concurrent COVID-19 infection and autoimmune diseases. <b>Case Summary:</b> In this paper, we present a case of a 9-year-old boy with yellowish discoloration of the skin and sclera, abnormal liver function test, followed by positive qRT-PCR for SARS-CoV-2 and progressive bicytopenia. After a lack of response to corticosteroids, intravenous immune globulin (IVIg) was administrated and a decline in liver enzymes, total bilirubin, and direct bilirubin was observed. <b>Result and Discussion:</b> This case illustrates how IVIg significantly improved the AIH symptoms in the patient with positive qRT-PCR for the SARS-CoV-2 test. We hope our report encourages further research on therapeutic approaches for AIH concomitant with COVID-19.

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Publication Details

Journal
Case Reports in Gastrointestinal Medicine
Published
2025-01-01
DOI
https://doi.org/10.1155/crgm/4446896
Primary Topic
Liver Diseases and Immunity
Type
article
Field-Weighted Citation Impact
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article

COVID‐19 Challenges in Autoimmune Hepatitis Management: A Successful Outcome With Intravenous Immune Globulin (IVIg)

A. Cyrus Arman, Parnian Khalili, Fereshteh Karbasian, Amirali Mashhadiagha et al.
Case Reports in Gastrointestinal Medicine
Liver Diseases and Immunity
article

COVID‐19 Challenges in Autoimmune Hepatitis Management: A Successful Outcome With Intravenous Immune Globulin (IVIg)

A. Cyrus Arman, Parnian Khalili, Fereshteh Karbasian, Amirali Mashhadiagha, Bita Geramizadeh, Maryam Ataollahi
article en

Abstract

<b>Background:</b> Several autoimmune diseases, such as autoimmune hepatitis (AIH), can arise or become decompensated following COVID-19 infection or vaccination; however, there is a lack of data regarding the management of concurrent COVID-19 infection and autoimmune diseases. <b>Case Summary:</b> In this paper, we present a case of a 9-year-old boy with yellowish discoloration of the skin and sclera, abnormal liver function test, followed by positive qRT-PCR for SARS-CoV-2 and progressive bicytopenia. After a lack of response to corticosteroids, intravenous immune globulin (IVIg) was administrated and a decline in liver enzymes, total bilirubin, and direct bilirubin was observed. <b>Result and Discussion:</b> This case illustrates how IVIg significantly improved the AIH symptoms in the patient with positive qRT-PCR for the SARS-CoV-2 test. We hope our report encourages further research on therapeutic approaches for AIH concomitant with COVID-19.

Case Reports in Gastrointestinal MedicineVol. 2025(1)
Iran University of Medical Sciences (IR), Shiraz University of Medical Sciences (IR)
Openalex Percentile: Top 91%
Liver Diseases and Immunity
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