A Well‐Defined Pd‐NHC Pre‐Catalyst for the Borylation of Aryl Chlorides
Abstract We report on the design of a new well‐defined Pd‐NHC pre‐catalyst [Pd(IMes Me )(cinnamyl)Cl] as effective catalyst in the Miyaura borylation of a series of aryl chlorides. This complex was designed and developed after a screening of different architectures of NHCs, featuring various steric and electronic properties. The synthesis was achieved by the operationally simple method of the weak‐base route, while a complete set of analytical techniques including 1 H NMR, 13 C NMR, and HRMS were employed for the characterization. Moreover, the structure and atom connectivity were unequivocally confirmed by X‐ray diffraction (XRD).
Authors
- Catherine S. J. Cazin (ORCID: https://orcid.org/0000-0002-9094-8131)
- Kristof Van Hecke (ORCID: https://orcid.org/0000-0002-2455-8856)
- Matthieu Jouffroy (ORCID: https://orcid.org/0000-0003-4478-2502)
- Miquel Gassiot i Matas
- Steven P. Nolan (ORCID: https://orcid.org/0000-0001-9024-2035)
- Leandros P. Zorba (ORCID: https://orcid.org/0000-0003-1447-4146)
- Gianluca Carì (ORCID: https://orcid.org/0000-0003-2411-7353)
- Tommaso Ruggiero
- Mathieu B. Plumereau
Institutions
- Janssen (Belgium) (BE)
- Ghent University (BE)
- Johnson & Johnson (Brazil) (BR)
- Universitat de Barcelona (ES)
- ESPCI Paris (FR)
Publication Details
- Journal
- ChemCatChem
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1002/cctc.202500267
- Citations
- 3
- Primary Topic
- Organoboron and organosilicon chemistry
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Fonds Wetenschappelijk Onderzoek