LC-MS/MS assay to confirm that the endogenous metabolite L-Arginine promotes trophoblast invasion in the placenta accreta spectrum through upregulation of the GPRC6A/PI3K/AKT pathway
Our study demonstrates that L-Arginine may promote trophoblast invasion and migration in placental implantation by upregulating the GPRC6A/PI3K/AKT pathway. This provides a new basis for screening appropriate metabolic markers for PAS, thus contributing to the prevention and treatment of PAS.
Authors
- Zhou Gao
- Min Xue
- Zhibiao Wang (ORCID: https://orcid.org/0000-0001-8148-2117)
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s12884-025-07475-6
- Citations
- 4
- Primary Topic
- Maternal and fetal healthcare
- Type
- article
- Field-Weighted Citation Impact
- 13.98