Stratifying Multiple Sclerosis Susceptibility Risk: The Role of <i>HLA‐E*01</i> and Infectious Mononucleosis in a Population Cohort
HLA-E*01:01 carriers diagnosed with IM are at significantly increased risk of MS, independently from other MS-related HLA alleles. This supports the hypothesis that HLA-E*01:01 may contribute to MS susceptibility due to weaker immune control over EBV infection. Incorporating HLA-E*01:01 into existing MHC-based MS risk models could then enhance personalized risk assessments in individuals with IM history.
Authors
- Teresa Fazia (ORCID: https://orcid.org/0000-0002-9577-8450)
- Sonia Bourguiba (ORCID: https://orcid.org/0000-0002-2452-2861)
- Davide Gentilini (ORCID: https://orcid.org/0000-0002-8391-0725)
- Andrea Nova (ORCID: https://orcid.org/0000-0002-7258-1938)
- Luisa Bernardinelli (ORCID: https://orcid.org/0000-0002-7551-6664)
- Nicolas Vince (ORCID: https://orcid.org/0000-0002-3767-6210)
- Giovanni Di Caprio (ORCID: https://orcid.org/0009-0003-1913-9897)
Institutions
- Inserm (FR)
- University of Pavia (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Nantes Université (FR)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/ene.70131
- Citations
- 3
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 2.39