Loperamide-induced severe cardiotoxicity: a toxicokinetic and toxicodynamic analysis derived from a case series and the published literature
Patients with chronic loperamide overdose are at risk of cardiotoxicity that persists for days due to persistent loperamide and N-desmethyl loperamide concentrations. We believe patients with loperamide overdose need an admission electrocardiograph and continuous monitoring until electrocardiographic changes resolve.
Authors
- Darren M. Roberts (ORCID: https://orcid.org/0000-0001-9101-7577)
- Judy Al Ahmad
- Angela L. Chiew (ORCID: https://orcid.org/0000-0002-0079-5056)
- Michael S. Roberts (ORCID: https://orcid.org/0000-0003-3894-5301)
- Úna Nic Ionmhain (ORCID: https://orcid.org/0000-0003-4818-4980)
- Lorraine Mackenzie (ORCID: https://orcid.org/0000-0002-6990-6324)
- Michael Tierney
- Stefanie Pidcock
- Faye Titania Whan
Institutions
- The University of Queensland (AU)
- University of South Australia (AU)
- University of Wollongong (AU)
- Fraser Institute (CA)
- Royal Prince Alfred Hospital (AU)
- Liverpool Hospital (AU)
- Wollongong Hospital (AU)
- UNSW Sydney (AU)
- Basil Hetzel Institute (AU)
- Western Regional Hospital (NP)
- Sydney Children’s Hospitals Network (AU)
Publication Details
- Journal
- Clinical Toxicology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1080/15563650.2025.2459763
- Citations
- 2
- Primary Topic
- Poisoning and overdose treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.51