Human menopausal gonadotropin (HMG) combined different doses of letrozole for treating anovulatory infertility in patients with polycystic ovary syndrome: a randomized controlled trial
Application of 5.0 mg LE followed with HMG does not improve the pregnancy rate compared to 2.5 mg LE in infertile women with PCOS. An increased dose of LE to 5.0 mg may increase the risks of OHSS and multiple pregnancies. Therapy of LE (2.5 mg) + HMG may be a more beneficial and optimal treatment protocol for improving endometrial receptivity and promoting mono-follicle development for patients with PCOS.
Authors
- Peng Yuan (ORCID: https://orcid.org/0000-0003-4627-8203)
- Xin Dai (ORCID: https://orcid.org/0000-0003-4343-6915)
- Xuefeng Long (ORCID: https://orcid.org/0000-0001-6121-545X)
- Yuqing Fang
- Wenqian Xiong (ORCID: https://orcid.org/0000-0002-7136-9265)
- Yi Liu (ORCID: https://orcid.org/0000-0002-4403-2325)
- Weiwei Li (ORCID: https://orcid.org/0000-0001-9145-8639)
- Jingyi Li (ORCID: https://orcid.org/0000-0003-1019-7030)
- Ling Zhang (ORCID: https://orcid.org/0009-0004-5274-9563)
- Xiuping Wang (ORCID: https://orcid.org/0000-0003-0888-7120)
Institutions
- Wuhan City Chinese Medicine Hospital (CN)
- Hubei 672 Orthopedics Hospital of Traditional Chinese Medicine and Western Medicine (CN)
- Wuhan No.1 Hospital (CN)
- Shandong Provincial Hospital (CN)
- Wuhan Union Hospital (CN)
- Shandong First Medical University (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Assisted Reproduction and Genetics
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1007/s10815-025-03455-z
- Citations
- 3
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.09
Funders
- Natural Science Foundation of Hubei Province
- Wuhan Union Hospital