Роль генетического полиморфизма PAI-1 4G/5G в развитии коронарной болезни сердца.

Background. The PAI-1 4G/5G genetic polymorphism plays an important role in the regulation of fibrinolysis and susceptibility to coronary artery disease (CAD). PAI-1 regulates the rate of thrombus destruction by limiting excessive plasminogen activation. Elevated PAI-1 levels play a key role in preventing both excessive thrombus formation and hyperfibrinolysis, which can lead to bleeding. An increase in PAI-1 promotes atherogenesis by reducing fibrinolysis and promoting the formation of stable atherosclerotic plaques, as well as vascular inflammation, which accelerates the progression of atherosclerosis. Materials and methods. A comprehensive analysis of literature data, clinical studies, and meta- analyses over the past 10 years related to the genetic polymorphism PAI-1 4G/5G was conducted. Results and conclusion. Literature data and various studies indicate a significant role of the genetic polymorphism PAI-1 4G/5G in the development of cardiovascular diseases.