Single-Cell Transcriptomic Landscape Deciphers Intratumoral Heterogeneity and Subtypes of Acral and Mucosal Melanomas
Our study provides a comprehensive comparison of AM and MM, uncovering subtype-specific stromal-immune interactions and molecular programs. The findings highlight actionable targets (e.g., TIGIT in AM and CXCL3+ macrophages in MM) and propose a framework for precision therapies, biomarker-driven trials, and risk stratification to improve outcomes in these aggressive melanomas.
Authors
- Cho Wing Li (ORCID: https://orcid.org/0000-0001-5777-3483)
- Zhi Wei (ORCID: https://orcid.org/0000-0001-6059-4267)
- Colin R. Goding (ORCID: https://orcid.org/0000-0002-1614-3909)
- Junfeng Shi (ORCID: https://orcid.org/0000-0001-7176-572X)
- Cang Li (ORCID: https://orcid.org/0009-0009-0513-4319)
- Yifan Chen (ORCID: https://orcid.org/0000-0002-3346-179X)
- Zhilin Zhang
- Hongmeng Yu (ORCID: https://orcid.org/0000-0002-2578-9103)
- Kai Wang (ORCID: https://orcid.org/0000-0003-4328-8799)
- Wantao Chen (ORCID: https://orcid.org/0000-0002-9307-162X)
- Xiao Miao (ORCID: https://orcid.org/0000-0003-3814-8329)
- Tao Li (ORCID: https://orcid.org/0000-0002-5924-0522)
- Zhi‐Xiang Xu (ORCID: https://orcid.org/0000-0002-2385-3044)
- Ziyang Cui (ORCID: https://orcid.org/0000-0001-5596-7196)
- Guoxin Ren (ORCID: https://orcid.org/0000-0003-0231-4938)
- Wenkang Qian (ORCID: https://orcid.org/0000-0002-1487-285X)
- Yunyan Li
- Z. Zhang (ORCID: https://orcid.org/0009-0009-7650-353X)
- Ronghao Zhang
- Xiaole Song (ORCID: https://orcid.org/0000-0002-9757-4937)
- Yeqing Chen (ORCID: https://orcid.org/0000-0002-5602-3311)
- Yongli Zhang (ORCID: https://orcid.org/0000-0003-1700-1352)
- Jianxin Chen (ORCID: https://orcid.org/0000-0003-4067-5638)
- Yong Chen (ORCID: https://orcid.org/0000-0002-7188-4566)
- Jiang Zhou (ORCID: https://orcid.org/0009-0001-3684-0218)
- Dongdong Jia (ORCID: https://orcid.org/0000-0002-6804-4988)
- Rutao Cui
- Xiaoqing Ma
Institutions
- The Wistar Institute (US)
- Zhejiang International Studies University (CN)
- New Jersey Institute of Technology (US)
- Shanghai Medical College of Fudan University (CN)
- Henan University (CN)
- Beijing University of Chinese Medicine (CN)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- University of Oxford (GB)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Zhejiang Cancer Hospital (CN)
- Ludwig Cancer Research (GB)
- Eye & ENT Hospital of Fudan University (CN)
- Peking University First Hospital (CN)
- Shuguang Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- University of Chinese Academy of Sciences (CN)
- Hangzhou Cancer Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3164
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China