Brachyury promotes proliferation and migration of colorectal cancer cells by targeting MMP14
Our findings highlight targeting the Brachyury-MMP14 axis as a potential novel approach for CRC clinical therapy.
Authors
- Yanjing Zhang (ORCID: https://orcid.org/0000-0003-3663-5633)
- Xiao Liang (ORCID: https://orcid.org/0000-0003-0330-7027)
- Huiheng Qu (ORCID: https://orcid.org/0000-0002-9268-2111)
- Jun Shen (ORCID: https://orcid.org/0000-0001-5171-0035)
- Jiazeng Xia (ORCID: https://orcid.org/0000-0003-0401-4824)
- Keqin Shi (ORCID: https://orcid.org/0000-0001-7378-8730)
- Pei‐Hua Lu (ORCID: https://orcid.org/0000-0002-4622-3061)
- Ying Huang (ORCID: https://orcid.org/0000-0003-4756-7939)
- Ming Chen (ORCID: https://orcid.org/0000-0002-3572-6886)
- Peng Chen (ORCID: https://orcid.org/0000-0002-3390-508X)
- Zhengjie Yang
- Hui Zhou (ORCID: https://orcid.org/0000-0002-2457-6309)
Institutions
- Jiangnan University (CN)
- Suzhou Municipal Hospital (CN)
- Wuxi No.2 People's Hospital (CN)
- Wuxi People's Hospital (CN)
- The Fifth People’s Hospital of Suzhou (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s12935-025-03726-w
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00