Induction of cellular autophagy impairs TGF-β1-mediated extracellular matrix deposition in primary human knee fibroblasts
Our findings demonstrate that the induction of cellular autophagy suppresses TGF-β1-induced collagen deposition in primary human knee fibroblasts. Taken together, these data suggest that cellular autophagy may be prophylactic against the pathogenesis of arthrofibrosis.
Authors
- Cole E. Bothun (ORCID: https://orcid.org/0009-0009-2761-0304)
- Mason F. Carstens
- Amel Dudakovic (ORCID: https://orcid.org/0000-0002-8850-3977)
- Daniel M. Berry (ORCID: https://orcid.org/0000-0002-6817-9081)
- Matthew P. Abdel (ORCID: https://orcid.org/0000-0002-2398-1724)
- Mark E. Morrey (ORCID: https://orcid.org/0000-0002-5031-8717)
- Joaquín Sánchez‐Sotelo (ORCID: https://orcid.org/0000-0003-3199-3247)
- Ashley N. Payne (ORCID: https://orcid.org/0000-0002-2639-6483)
- Oliver B. Dilger
- Roman Thaler
Institutions
- Mayo Clinic (US)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1302/2046-3758.144.bjr-2024-0312.r1
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Amgen
- Stryker
- Regenerative Medicine Minnesota
- Anna-Maria and Stephen Kellen Foundation
- American Association of Hip and Knee Surgeons
- National Institutes of Health