Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis
These findings suggest that NR confers neuroprotection by attenuating damaged DNA-triggered STING-mediated microglial activation and pyroptosis. Targeting the cGAS-STING pathway presents a promising therapeutic avenue for retinal degeneration.
Authors
- Yubing Zhou (ORCID: https://orcid.org/0000-0002-4680-726X)
- Lusi Zhang (ORCID: https://orcid.org/0000-0001-6659-7944)
- Guangshuang Tan
- Shanshan Zhu (ORCID: https://orcid.org/0000-0001-7148-6659)
- Qian Jiang (ORCID: https://orcid.org/0000-0002-8504-7857)
- Zewei Wang (ORCID: https://orcid.org/0000-0001-9369-4109)
- Jiawei Chen (ORCID: https://orcid.org/0000-0002-4874-3474)
- Cong Wang (ORCID: https://orcid.org/0000-0001-7831-3486)
- Xian Zhang (ORCID: https://orcid.org/0000-0003-4079-9470)
- Jingyuan Liu (ORCID: https://orcid.org/0000-0001-5624-1258)
- Ping Tong (ORCID: https://orcid.org/0000-0001-9273-1676)
- Bing Jiang (ORCID: https://orcid.org/0000-0001-6594-4019)
- Peiyun Duan
Institutions
- Central South University (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1167/iovs.66.4.14
- Citations
- 8
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- National Natural Science Foundation of China
- Xiangya Hospital, Central South University