Visible Light-Induced Tandem Radical Cyclization for the Synthesis of 2-(3-Cyanoalkyl)Substituted Quinoline Derivatives
A highly efficient 6-endo-trig radical cyclization reaction between cyclobutanone oximes and 1-isocyano-2-vinylbenzenes via visible light-induced photoredox catalysis has been realized in the presence of 2 mol % of <i>fac</i>-Ir(ppy)<sub>3</sub> as the photocatalyst, which gave rise to a variety of 2-(3-cyanoalkyl)substituted quinoline derivatives with moderate to excellent yields under mild reaction conditions.
Authors
- Guichao Wang (ORCID: https://orcid.org/0000-0002-7293-5732)
- Aiyu Chen (ORCID: https://orcid.org/0000-0003-1819-7449)
- Caiyun Liang (ORCID: https://orcid.org/0000-0001-9866-7863)
- M. J. Guo (ORCID: https://orcid.org/0000-0002-8770-0856)
- Wuheng Dong (ORCID: https://orcid.org/0000-0003-1310-6018)
- Wanfang Li (ORCID: https://orcid.org/0000-0002-2544-1756)
- Guanzhong Chen (ORCID: https://orcid.org/0000-0003-3609-2288)
- Bin Li (ORCID: https://orcid.org/0000-0002-8348-7445)
- Yongchun Huang (ORCID: https://orcid.org/0000-0003-0637-3791)
- Zuodong Yin
Institutions
- University of Shanghai for Science and Technology (CN)
- Guangxi University (CN)
- Guangxi University of Science and Technology (CN)
- Chemical Synthesis Lab (SG)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1021/acs.joc.4c02542
- Citations
- 2
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- National Natural Science Foundation of China
- Guangxi University of Science and Technology
- Specific Research Project of Guangxi for Research Bases and Talents