Copper‐Catalyzed <i>α</i>, <i>β</i>‐Enone Allylic Aerobic Oxidation to 1,4‐Enedione
Abstract A general, efficient and economic copper‐catalyzed α, β ‐enones allylic oxidation to 1,4‐enedione has been developed. The protocol only requires a small amount of cheap copper catalyst with air as the sole oxidant. The advantages of the approach are mild reaction conditions, a broad substrate scope, good tolerance of functional groups, and easy experimental operation. The approach has been demonstrated to be compatible for the late‐stage functionalization of drugs and natural products.
Authors
- Qing Su (ORCID: https://orcid.org/0000-0003-1462-4503)
- Chong Luo (ORCID: https://orcid.org/0000-0002-6650-1022)
- Yaru Gao (ORCID: https://orcid.org/0000-0002-6057-1652)
- Yong‐Qiang Wang
- Hongxia Zhang
- Qiong Jia (ORCID: https://orcid.org/0000-0003-0182-6579)
- Li-Gang Kou
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Northwest University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1002/adsc.202500221
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China